TABLE OF CONTENTS

Introduction

Benefits of Pacing

Surgical Procedure

Demographics of Pacing

Laproscopic Technology

The Future

Links for More Information

The Group

BI108 Website

Brown University

The Device

Mark IV References

The Device

The device provides electrical stimulation to the muscle and nerves that run through the diaphragm. When the muscle is stimulated, it contracts, causing a vacuum-like effect in the chest cavity that causes air to enter the lungs. When the contraction eases, the air is expelled passively. This process is repeated 10-14 times per minute. This is essentially the same process as normal breathing.


The pacing system consists of:
  • Four Teflon embedded Electrodes: deliver a pulse directly to the phrenic nerve causing the diaphragm muscle to contract.
    • The quadripolar system sequentially stimulates each of the four electrodes during a given breath, thereby decreasing the number of impulses delivered to a single quadrant of the phrenic nerve by 75% during inspiration. This quadripolar electrode system aims to eliminate the potential for diaphragm fatigue with prolonged pacing and allow for the situation-specific manipulation of pacer settings to meet the needs of an individual through stimulation setting changes by programming modules and the stimulus controller.
  • Platinum/Stainless Steel Leads: connect the electrodes to the receiver and transmitter
  • Radio receivers: translate the radio waves and stimulate the pulses.
    • The radio receiver has a connector that is screwed into a titanium disc with an axial flange covered entirely by a woven double velour patch, which provides a barrier to infection.
    • The electrode wires are crimped to the connector and embedded in silicone rubber.
  • External transmitter/antenna assembly (portable control unit): receives its power from 9 volt batteries and sends energy and stimulus information to the patient.s receiver implant.


Mark IV Transmitter

The Mark IV Transmitter is already in PMA phase has many advantages over the current model (S-232G)

Mark IV
  • Bilateral redundancy, including dual batteries - The bilaterally redundant design of the Mark IV provides greater safety than the S-232G transmitter.
  • Amplitude range control - The Mark IV transmitter can provide greater resolution of stimulus amplitude by limiting the maximum output level.
  • External breathing rate control - The Mark IV transmitter has the respiratory rate control (with a locking option) on the front panel. This is easier to operate than the S-232G transmitter, whose respiratory rate control was located in the battery compartment.
  • Capability for a wider range of stimulus parameters - The Mark IV can be custom modified more easily than the S232G transmitter, should a patient require stimulus parameters that are different from the factory standard settings.
  • Capability for asymmetrical parameters - Patients may require that parameters be set differently from one side of the body to the other. Such asymmetrical adjustment is not possible with an S-232G transmitter.
  • Introduction of battery indicators - The Mark IV battery indicators use the latest advancements in light emitting diode (LED) technology to provide a simple, reliable method to verify adequate battery voltage and that the transmitter power circuitry is functioning.
  • Introduction of antenna indicators - Like the battery indicators, the Mark IV antenna indicators provide a simple, reliable method to verify stimulus output and antenna integrity.
  • Single circuit board design - The single printed circuit board design of the Mark IV is inherently more reliable then the dual circuit board design of the S-232G transmitter.
  • Readily available electronic components - All electronic and mechanical components used in the Mark IV are in current production and readily available.


References
http://fesnet.eng.gla.ac.uk/conference/X_SONIB.DOC
Artificial Organs. 1999; 23(9): 860-868
http://www.christopherreeve.org/news/news.cfm?ID=449&c=30
http://www.averylabs.com/